ARDS : What Is It, And What Does PubMed Say About Glutathione?

ARDS, or Acute Respiratory Distress Syndrome, is an acute, life-threatening respiratory failure following pulmonary or lung injury.

According to Dr. Jimmy Gutman, in his book, "Glutathione - Your Key to Health", Acute Respiratory Distress Syndrome leads to profound dyspnea (shortness of breath), pulmonary edema (fluid accumulation in the lung) and hypoxemia (oxygen starvation).

ARDS is a very complicated inflammatory process, and in the past, physicians treated this disorder aggressively with corticosteroids, to counteract inflammation. Unfortunately, randomized trials have shown that steroids are relatively ineffective against this disease.

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Recent research points to the role of glutathione as an antioxidant and anti-inflammatory agent in the role of ARDS treatment. For several reasons, ARDS patients experience high levels of oxidative stress and subsequently have depleted levels of antioxidants and glutathione.

In early September 2009, a search on PubMed, which is a repository of published medical research from around the world, brought up 102 references for the search "Adult Respiratory Distress Syndrome". You can learn more about PubMed here.

I have selected 10 of these studies here for your perusal, and they all open in a new window. Closing the window will bring you back to this page.

Acute Respiratory Distress Syndrome Study #1:

The role of glutathione-S-transferase polymorphisms on clinical outcome of ALI/ARDS patient treated with N-acetylcysteine. Respir Med. 2009 Mar;103(3):434-41. Epub 2008 Nov 7

Moradi M, Mojtahedzadeh M, Mandegari A, Soltan-Sharifi MS, Najafi A, Khajavi MR, Hajibabayee M, Ghahremani MH. Department of Clinical Pharmacy, Tehran University of Medical Sciences, Iran.


Acute Respiratory Distress Syndrome Study #2:

Ability of antioxidant liposomes to prevent acute and progressive pulmonary injury.

Antioxid Redox Signal. 2008 May;10(5):973-81.

Hoesel LM, Flierl MA, Niederbichler AD, Rittirsch D, McClintock SD, Reuben JS, Pianko MJ, Stone W, Yang H, Smith M, Sarma JV, Ward PA. Department of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109-0602, USA.


Acute Respiratory Distress Syndrome Study #3:

Improvement by N-acetylcysteine of acute respiratory distress syndrome through increasing intracellular glutathione, and extracellular thiol molecules and anti-oxidant power: evidence for underlying toxicological mechanisms. Hum Exp Toxicol. 2007 Sep;26(9):697-703

Soltan-Sharifi MS, Mojtahedzadeh M, Najafi A, Reza Khajavi M, Reza Rouini M, Moradi M, Mohammadirad A, Abdollahi M. Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.


Acute Respiratory Distress Syndrome Study #4:

Sulfur-containing compounds in protecting against oxidant-mediated lung diseases.

Curr Med Chem. 2007;14(24):2590-6.

Pappa A, Franco R, Schoneveld O, Galanis A, Sandaltzopoulos R, Panayiotidis MI. Department of Molecular Biology and Genetics, Democritus University of Thrace, Greece.

Acute Respiratory Distress Syndrome Study #5:

Silymarin, the antioxidant component of Silybum marianum, prevents sepsis-induced acute lung and brain injury. J Surg Res. 2008 Apr;145(2):214-22. Epub 2007 Oct 22

Toklu HZ, Tunali Akbay T, Velioglu-Ogunc A, Ercan F, Gedik N, Keyer-Uysal M, Sener G. Department of Pharmacology, School of Pharmacy, Marmara University, Istanbul, Turkey.

Acute Respiratory Distress Syndrome Study #6:

The alcoholic lung: epidemiology, pathophysiology, and potential therapies. Am J Physiol Lung Cell Mol Physiol. 2007 Apr;292(4):L813-23. Epub 2007 Jan 12.

Joshi PC, Guidot DM. Atlanta Veterans Affairs Medical Center, Atlanta, Georgia GA 30033, USA. pcjoshi@emory.edu

Acute Respiratory Distress Syndrome Study #7:

[Alcohol abuse as a risk factor for ARDS]

Nihon Arukoru Yakubutsu Igakkai Zasshi. 2006 Oct;41(5):400-6

[Article in Japanese]

Wakabayashi I, Kato H. Department of Hygiene and Preventive Medicine, Yamagata University School of Medicine, Iida-Nishi 2-2-2, Yamagata 990-9585, Japan.

Acute Respiratory Distress Syndrome Study #8:

Antioxidant strategies in respiratory medicine. Treat Respir Med. 2006;5(1):47-78

Christofidou-Solomidou M, Muzykantov VR. Institute of Environmental Medicine and Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

Acute Respiratory Distress Syndrome Study #9:

Alcohol-induced lung damage and increased oxidative stress. Respiration. 2006;73(1):100-4. Epub 2005 Sep 29

Aytacoglu BN, Calikoglu M, Tamer L, Coşkun B, Sucu N, Köse N, Aktas S, Dikmengil M. Department of Cardiovascular Surgery, Mersin University School of Medicine, Mersin, Turkey. baytacoglu@yahoo.com

Acute Respiratory Distress Syndrome Study #10:

Chronic ethanol ingestion and the risk of acute lung injury: a role for glutathione availability? Alcohol. 2004 Jul;33(3):191-7

Brown LA, Harris FL, Ping XD, Gauthier TW. Department of Pediatrics, Emory University, 2015 Uppergate Drive, NE, Atlanta, GA 30322, USA. lbrow03@emory.edu

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In conclusion, there is much published research available for the role of oxidative stress, antioxidants, and glutathione in the disease known as ARDS or Adult Respiratory Distress Syndrome. You can learn more about how to raise glutathione here.

By raising and sustaining your glutathione levels, much can be done to protect yourself from ARDS and other pulmonary diseases.


Dr. Jimmy Gutman is the world's most published author on the subject of glutathione. His current bestseller is entitled "Glutathione - Your Key To Health."

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