Alzheimers Disease Prevention - Access Glutathione Research Here!

Many today would like to know about Alzheimers Disease prevention. They would also like to know about Alzheimer’s Disease care, and also Alzheimer’s treatment. Are there studies on Alzheimer’s Disease that help in this regard? Note: For the benefits of searchers, the page will use Alzheimers Disease and Alzheimer's Disease interchangeably.)

PubMed (www.pubmed.gov), which is sponsored by the National Institute of Health, contains a repository of published medical studies from around the world. You can

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In July 2011, a search for “glutathione Alzheimer’s" returned 703 results. Many of these point to the role of glutathione as an antioxidant to combat oxidative stress as a causative factor. Vascular dementia is considered, as well as senile dementia,

lipid peroxidation, as well as information on Alzheimer’s prevention and Alzheimer’s treatment through glutathione up-regulation.

I have chosen 10 of these studies here for your perusal.


Alzheimers Disease Prevention: Study #1

Systemic Oxidative Stress Associated with the Neurological Diseases of Aging.
Neurochem Res. 2009 Jun 2. [Epub ahead of print]

Serra JA, Domínguez RO, Marschoff ER, Guareschi EM, Famulari AL, Boveris A.

Free Radicals Program, Programa de Radicales Libres (PRALIB), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Oxidative Stress Laboratory, Faculty of Pharmacy and Biochemistry, University of Buenos Aires (UBA), Junín 954, C1113AAD, Buenos Aires, Argentina, jserra@ffyb.uba.ar.


Alzheimers Disease Prevention: Study #2

Reduced glutathione is highly expressed in white matter and neurons in the unperturbed mouse brain--implications for oxidative stress associated with neurodegeneration. Brain Res. 2009 Jun 18;1276:22-30. Epub 2009 Apr 22.

Miller VM, Lawrence DA, Mondal TK, Seegal RF. Biggs Laboratory, Wadsworth Center, New York State Department of Health, Empire State Plaza, Albany, NY 12201, USA. veronica.miller2@mail.dcu.ie

Alzheimers Disease Prevention: Study #3

Glutathione dysregulation and the etiology and progression of human diseases.
Biol Chem. 2009 Mar;390(3):191-214.

Glutathione dysregulation and the etiology and progression of human diseases. Ballatori N, Krance SM, Notenboom S, Shi S, Tieu K, Hammond CL. Department of Environmental Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA. Ned_Ballatori@urmc.rochester.edu

Alzheimers Disease Prevention: Study #4

Increased oxidative stress and astrogliosis responses in conditional double-knockout mice of Alzheimer-like presenilin-1 and presenilin-2.

Free Radic Biol Med. 2008 Nov 15;45(10):1493-9. Epub 2008 Sep 13.

Zhu M, Gu F, Shi J, Hu J, Hu Y, Zhao Z. Key Laboratory of Brain Functional Genomics, Ministry of Education of China and the Science and Technology Commission of Shanghai Municipality, Shanghai Institute of Brain Functional Genomics, East China Normal University, Shanghai 200062, China.

Alzheimers Disease Prevention: Study #5

Peripheral oxidative damage in mild cognitive impairment and mild Alzheimer's disease.

J Alzheimers Dis. 2008 Sep;15(1):117-28.

Baldeiras I, Santana I, Proença MT, Garrucho MH, Pascoal R, Rodrigues A, Duro D, Oliveira CR. Laboratory of Neurochemistry, Neurology Department, Coimbra University Hospital, Coimbra, Portugal. ines.baldeiras@sapo.pt

Alzheimers Disease Prevention: Study #6

Lipid peroxidation up-regulates BACE1 expression in vivo: a possible early event of amyloidogenesis in Alzheimer's disease.

J Neurochem. 2008 Oct;107(1):197-207. Epub 2008 Aug 2.

Chen L, Na R, Gu M, Richardson A, Ran Q. Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, Texas, USA.

Alzheimers Disease Prevention: Study #7

Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease.

Adv Drug Deliv Rev. 2008 Oct-Nov;60(13-14):1463-70. Epub 2008 Jul 4.

Maczurek A, Hager K, Kenklies M, Sharman M, Martins R, Engel J, Carlson DA, Münch G. Department of Pharmacology, School of Medicine, University of Western Sydney, Australia.

Alzheimers Disease Prevention: Study #8

The antioxidant role of glutathione and N-acetyl-cysteine supplements and exercise-induced oxidative stress.

J Int Soc Sports Nutr. 2005 Dec 9;2:38-44.

Kerksick C, Willoughby D. Exercise and Sport Nutrition Laboratory, Baylor University, Waco, TX. Chad_Kerksick@baylor.edu.

Alzheimers Disease Prevention: Study #9

A mathematical model of glutathione metabolism.

Theor Biol Med Model. 2008 Apr 28;5:8.

Reed MC, Thomas RL, Pavisic J, James SJ, Ulrich CM, Nijhout HF. Department of Mathematics, Duke University, Durham, NC 27708, USA. reed@math.duke.edu

Alzheimer's Disease Prevention: Study #10

[The two faces of reactive oxygen species]

Postepy Hig Med Dosw (Online). 2008 Mar 26;62:118-24.

[Article in Polish]

Zabłocka A, Janusz M. Instytut Immunologii i Terapii Doświadczalnej PAN im. L. Hirszfelda we Wrocławiu. zablocka@iitd.pan.wroc.pl

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In conclusion, we can see from published medical studies that oxidative stress plays a key role in the causes of Alzheimer’s Disease. By raising glutathione levels, the body’s master antioxidant, much can be done for Alzheimer’s prevention.

Glutathione and it’s related enzyme glutathione peroxidase also help to prevent lipid peroxidation, which may also be a causative factor in Alzheimer’s Disease. This can help to prevent symptoms of vascular dementia, and senile dementia. These studies on Alzheimer’s Disease show us that much can be gained by raising and sustaining our glutathione levels for Alzheimer’s prevention and Alzheimer’s treatment.


Dr. Jimmy Gutman is the world's most published author on the subject of glutathione. His current bestseller is entitled "Glutathione - Your Key To Health."

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