Is Liposomal Glutathione or Lipoceutical Glutathione Effective?
I am aware that glutathione pills are not effective in raising glutathione.
However, I found something called Liposomal Glutathione, or Lypo-Spheric GSH, made by LivOn Labs, that claims it works to raise glutathione. It is supposed to be absorbed easily into your body using liposome technology.
Please, is this accurate, advisable, and true?
That is an excellent question. Since the subject of liposomal glutathione is not addressed in Dr. Gutman's handbook on glutathione, I checked with him directly. Here, in part, is his response:
"Despite the appearance of 300-400 articles on PubMed when entering “liposomal glutathione”, these articles are not about the product “Lypo-Spheric GSH”. Most of them are about other molecules that appear in a liposomic form (like chemotherapy agents) and how glutathione may relate to the effect.
The only article where I actually saw liposomal glutathione used successfully in a human trial, was when it was put into an aerosol and inhaled. This is not such a big thing however, since inhaled glutathione itself works as well.
If you are aware of ANY human studies using liposomal glutathione, I will be very interested in seeing them.
The issue of oral glutathione is far more complicated than “it gets broken down in the digestive tract”. This is an explanation given for the sake of brevity and understanding for a layperson.
Just to give some insight into some of the details, even when glutathione makes it into the blood stream, it generally is not absorbed into a cell. There are only a few cell types that have a transport mechanism that does this across the cell wall. For the vast majority of cells, the GSH molecule is too big.
Dr. Wolf Droge explains the success of intravenous glutathione by pointing out the glutathione first must break down into its amino acid components, and hopefully some of the cysteine gets transported into the cells.
It is a complete leap of faith to assume that oral liposomal glutathione gets glutathione into the bloodstream. I have not seen a shred of clinical evidence that this happens.
Much of the information given on the Lypo-Spheric GSH webpage is very questionable, such as claims that using precursors must depend on sickly cells to reconstruct GSH once the building blocks arrive, and that reconstruction is not guaranteed.
Although no strategy is “guaranteed”, this statement still flies in the face of hundreds of articles on thousands of patients successfully using glutathione precursors. There are over 30 years of published research on Immunocal, the product which I have endorsed for years.
In the absence of published evidence to the contrary, I state again, GSH is not effectively transported across the cell membranes. Based on published research, until we see evidence to the contrary, I would say that taking liposomal glutathione to raise your glutathione is not substantiated.
By the way, PubMed is a tough read. You have to be able to dissect the articles, some of which require the knowledge of an entirely new language. This can be challenging enough even for a doctor, let alone the layperson.
Dr. Jimmy Gutman"
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