Is Liposomal Glutathione or Lipoceutical Glutathione Effective?

by Elizabeth
(NY, NY)

I am aware that glutathione pills are not effective in raising glutathione.

However, I found something called Liposomal Glutathione, or Lypo-Spheric GSH, made by LivOn Labs, that claims it works to raise glutathione. It is supposed to be absorbed easily into your body using liposome technology.

Please, is this accurate, advisable, and true?

That is an excellent question. Since the subject of liposomal glutathione is not addressed in Dr. Gutman's handbook on glutathione, I checked with him directly. Here, in part, is his response:

"Despite the appearance of 300-400 articles on PubMed when entering “liposomal glutathione”, these articles are not about the product “Lypo-Spheric GSH”. Most of them are about other molecules that appear in a liposomic form (like chemotherapy agents) and how glutathione may relate to the effect.

The only article where I actually saw liposomal glutathione used successfully in a human trial, was when it was put into an aerosol and inhaled. This is not such a big thing however, since inhaled glutathione itself works as well.

If you are aware of ANY human studies using liposomal glutathione, I will be very interested in seeing them.

The issue of oral glutathione is far more complicated than “it gets broken down in the digestive tract”. This is an explanation given for the sake of brevity and understanding for a layperson.

Just to give some insight into some of the details, even when glutathione makes it into the blood stream, it generally is not absorbed into a cell. There are only a few cell types that have a transport mechanism that does this across the cell wall. For the vast majority of cells, the GSH molecule is too big.

Dr. Wolf Droge explains the success of intravenous glutathione by pointing out the glutathione first must break down into its amino acid components, and hopefully some of the cysteine gets transported into the cells.

It is a complete leap of faith to assume that oral liposomal glutathione gets glutathione into the bloodstream. I have not seen a shred of clinical evidence that this happens.

Much of the information given on the Lypo-Spheric GSH webpage is very questionable, such as claims that using precursors must depend on sickly cells to reconstruct GSH once the building blocks arrive, and that reconstruction is not guaranteed.

Although no strategy is “guaranteed”, this statement still flies in the face of hundreds of articles on thousands of patients successfully using glutathione precursors. There are over 30 years of published research on Immunocal, the product which I have endorsed for years.

In the absence of published evidence to the contrary, I state again, GSH is not effectively transported across the cell membranes. Based on published research, until we see evidence to the contrary, I would say that taking liposomal glutathione to raise your glutathione is not substantiated.

By the way, PubMed is a tough read. You have to be able to dissect the articles, some of which require the knowledge of an entirely new language. This can be challenging enough even for a doctor, let alone the layperson.

Dr. Jimmy Gutman"

You can order Immunocal here. To qualify for a 20% or 30% discount on your order, please click here.

Comments for Is Liposomal Glutathione or Lipoceutical Glutathione Effective?

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Apr 03, 2013
Liposomal Gluthaione by Anonymous 1 Feb 2013
by: Anonymous

Please post whatever responses you get to your enquiry. I would be very interested in hearing the answer since I was considering starting taking Lioposomal Glutathione to help combat MND/ALS.

The answers and information here are comprehensive, and there is no further room for posting. If you wish to try Immunocal, you may do so here:

Immunocal remains the most effective, safe, and natural way to raise and sustain your glutathione.

You can order Immunocal here. To qualify for a 20% or 30% discount on your order, please click here.

Feb 01, 2013
Liposomal Gluthaione
by: Anonymous

I found a study that shows a liposomal glutathione product being tracked (using cesium) to pass through the cell wall and into the cell. I am personally waiting for a response from the company that posted this study as to what percentage of their product was found within the cells. In general, this company likes to talk only to the professionals, not the consumers, so I went through my compounding pharmacist for this.

Aug 31, 2011
Whey Protein Is Not For Everyone
by: Anonymous

Whey protein is not well tolerated by many. What about someone with casein allergies? Most doctors don't want to administer anything with gluten or casein.

Even if liposomal glutathione is broken down into the 3 amino acids, if it's able to increase the amount of cysteine in the blood, you increase the likelihood of cysteine being taken into the red blood cells where glutathione is formed. So liposomal glutathione can in fact indirectly increase cellular levels of glutathione. That's no different than whey protein- it indirectly increases glutathione levels.


Thank you for your observations. The only people that cannot tolerate Immunocal are those with specific milk protein allergies, and those who are on immunosuppressant drugs. The lactose, casein, and fat have been removed, so a person with casein allergies, or lactose intolerance, can safely take it. Doctors have no problem prescribing Immunocal for their patients.

This is also stated on the PDR listing for Immunocal. Immunocal is also gluten, additive, filler, and preservative free. If a person was able to breastfeed as an infant, then they can also tolerate Immunocal.

As always, I stick to published research on the facts as it relates to glutathione. I have yet to see published research for the effectiveness of lipoceutical glutathione in humans.

Lipoceutical glutathione does not claim to break down into its components, but rather claims that the glutathione molecule enters the cells intact. However, if it breaks down as you suggest, there are cautions with circulating free cysteine in the body, such as hypercystinemia, and this is commented on in my glutathione side effects page.

Immunocal is indeed very different, because it is bonded cysteine, or two cysteines linked together (cystine), not free cysteine. The difference is important and crucial to understanding how it is processed and used in the body. Bonded cysteine is the form that Nature first intended us, and all mammals, to receive it - in mother's milk. It is very effective, and intelligently designed.

If lipoceutical glutathione is effective in raising GSH intracellularly in humans, this will be borne out by published research, and it will join the list of many ways to raise glutathione which I have already commented on my site. I comment on them all, not just Immunocal.

After years of research, I have come to the conclusion that Immunocal represents the safest, most effective, natural way to raise and sustain your glutathione. Nature knew best, and this is borne out by published research.

It's not the only way, just the one I personally recommend. We all have a choice to make, and I'm glad you have found something that works for you. Thanks again for your great comments!

Aug 27, 2011
by: Christine

The product called Lipoceutical Glutathione is very effective. My doctor showed me the 3 articles that have been published in (mainstream) scientific journals regarding this product. Call the company if you want more information. I am sure they will share it with you.

It has helped me enormously ... so much more than precursors.. to detoxify. Check it out.

Immune Health Solutions:

Thanks, Christine. I've done just that- I've written the company and asked them to back up their statements about precursors and also for their published research. I'm still waiting to hear back from them.

Immune Health Solutions, Follow Up 1/13/2012:

After waiting for a few months to receive published results from LivOn for their product, and receiving no reply, I did my own search on PubMed. By using quotation marks to isolate the term, I found a total of 5 studies that mention either term.

No brand names were used, but here is what I found as of 1/13/2012:

For Lipoceutical Glutathione:

A clinical trial of glutathione supplementation in autism spectrum disorders.

For Liposomal Glutathione:

Liposomal-glutathione provides maintenance of intracellular glutathione and neuroprotection in mesencephalic neuronal cells.

Anti-oxidant and anti-atherogenic properties of liposomal glutathione: studies in vitro, and in the atherosclerotic apolipoprotein E-deficient mice.

Reduction of oxidative stress marker in lung fluid of preterm infants after administration of intra-tracheal liposomal glutathione.

Hepatic lipid peroxidation: caused by acute drug intoxication, prevented by liposomal glutathione.

As mentioned on my how to raise glutathione page, there are many well known and researched ways to raise your glutathione.

It can be difficult to decipher the results of medical studies, even if you have your medical degree. If you have a product that's been well researched for over thirty years and is published in 27 studies on PubMed, and in your doctor's PDR, you have a long, successive and definitive track record.

Dr. Jimmy Gutman regularly updates his bestselling book about glutathione, and as he does, based on published research, Immune Health Solutions will bring this information to you.

Bottom Line: Do your own research, make the best choice for you, and Good Health To You!

* Update: Dr. Jimmy Gutman has provided comments for us on these studies, and due to space restrictions, these can be found here.

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